Metformin for Antipsychotic-Induced Weight Gain in Adolescents
The Carlat Psychiatry Report, Volume 5, Number 3, March 2007
https://www.thecarlatreport.com/newsletter-issue/tcprv5n3/
Issue Links: Learning Objectives | Editorial Information
Topics: Antipsychotics
William Carpenter, MD
Atypical antipsychotics can cause significant weight gain in adolescents. In this study, 39 kids between 10 and 18 years of age were randomized to receive either the antidiabetic drug Glucophage (metformin) or a matched placebo; each was added to their primary antipsychotic medication (Risperdal, Seroquel, or Zyprexa) for 16 weeks.
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William Carpenter, MD
Editor-in-Chief, Schizophrenia Bulletin; Professor, Psychiatry and Pharmacology, and Director, Maryland Psychiatric Research Center University of Maryland School of Medicine, Baltimore
Dr. Carpenter has disclosed that he has served as a consultant to Alza, AstraZeneca, Janssen Pharmaceutica, Merck, Pfizer, and Solvay/Wyeth, and that he has received less than $5,000 for each consultancy. Dr. Carlat has reviewed and edited the content to ensure a balanced and unbiased presentation.