Prazosin

Clinical Update

Assessment and Treatment of PTSD in the Older Patient

Topics: clonidine | Cognitive Behavioral Therapy | cognitive processing therapy | Eye movement desensitization and reprocessing | PCL-5 | Prazosin | Prolonged exposure | PTSD | screening | Trauma | Trauma-focused psychotherapy

Your patient, Jonathan, is a 71-year-old man with a history of depression. Two months ago, he was a passenger in a car accident in which the driver was killed. Now he reports sleeping poorly due to nightmares and complains about headaches and stomachaches. He tells you he can’t stop thinking about what happened and needs convincing to get into a car,

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Research Update

Another Black Eye for Prazosin in PTSD?

Topics: Hypnotics | Insomnia | Nightmares | Prazosin | PTSD | Research | Research Update | Sleep | Suicidality

Review of: McCall W et al, J Clin Psychopharmacol 2018;38(6):618–621 Study Type: Randomized single-blind controlled trial (pilot study) Prazosin has become a mainstay in the pharmacologic treatment of PTSD. A selective antagonist of the noradrenergic alpha-1 receptor, it has modest benefits in sleep and nightmares that are supported by around ha

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