Anticholinergic Drugs and Risk of Cognitive Impairment and Dementia

Topics: Alzheimers | Anticholinergic burden scale | Anticholinergics | Benzodiazepines | Cognitive Decline | Cognitive impairment | Dementia | Healthy aging | Pharmacotherapy

CHPR: Can you tell us about your research? Dr. Gray: My research uses large databases to examine medication safety issues in older adults with the goal of optimizing healthy aging. My focus is on examining medications and risk for dementia, falls, and fractures—the types of outcomes that are not easily addressed in randomized controlled trials. CH

Melatonin vs Memantine for ECT-Related Cognitive Impairment

Topics: Cognitive impairment | ECT | Melatonin | Memantine

Review of: Sarraf N et al, J Clin Neurosci 2020;74:146–150 Many patients hesitate to accept ECT because of the treatment’s adverse effects on cognitive function. Memantine (Namenda)—an NMDA receptor antagonist approved for the treatment of Alzheimer’s disease—has been shown to be more effective than placebo in preventing cognitive impairmen