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After reading these articles, you should be able to:

1. Describe some of the pharmacologic approaches to treatment-resistant depression.
2. Evaluate the effectiveness of the newer drugs vilazodone (Viibryd), levomilnacipran (Fetzima), vortioxetine (Brintellix), and ketamine in treating depression.
3. Determine the effectiveness of using light therapy to treat non-seasonal depression.