Serious But Rare Antidepressant Side Effects

Topics: Antidepressants

We typically warn our patients about common side effects, such as headache, GI distress and sexual dysfunction when we start SSRIs. Here are some of the side effects that we don’t necessarily talk to patients about, but should be able to recognize and discuss in particular contexts. Bleeding SSRIs famously inhibit the reuptake of serotonin in th

Apparent effectiveness of antidepressants is inflated by publication bias

Topics: Antidepressants

Antidepressants are effective primarily for severe depression

Topics: Antidepressants

Does Concerta augmentation of antidepressants work?

Topics: Antidepressants

Confusing presentation of data leads to premature condemnation of black box warnings

Topics: Antidepressants

Exercise may be as effective as sertraline

Topics: Antidepressants | Research Updates

Do SSRIs cause osteoporosis?

Topics: Antidepressants

Metaanalysis shows no difference between SSRIs and bupropion

Topics: Antidepressants

Zoloft not helpful for subsyndromal symptoms in cancer patients

Topics: Antidepressants

Antidepressant suicide warning for young adults

Topics: Antidepressants

Antidepressants shown ineffective for bipolar depression

Topics: Antidepressants | Anxiety Disorder

Does “California Rocket Fuel” Work?

Topics: Antidepressants | Free Articles

September 2019 update on this topic: When a popular antidepressant combination is discredited, what do we do with it? Dr. Chris Aiken sorts through the possibilities for mirtazapine (Remeron) augmentation, and pulls up a few more myths about this medicine. Listen to the podcast episode below or read full article this episode is based on from the Septemb

Bad News for Transcranial Magnetic Stimulation

Topics: Antidepressants

Clarifying the Risks of Antidepressants

Topics: Antidepressants

SSRI Nonresponse: What to do Next?

Topics: Antidepressants

By Shalom Feinberg, M.D. Most psychiatrists would agree that the first step in treating depression is to start one of SSRIs, because they are effective, safe, have a broad spectrum of both anti-anxiety and antidepressant activity, and are often cheap, since all SSRIs but Lexapro are now available generically. How cheap is cheap? At Walmart pharmacies

Suicidality and Antidepressants

Topics: Antidepressants

Deciphering Antidepressant Research

Topics: Antidepressants | Understanding Psychiatric Research

The First Antidepressant

Topics: Antidepressants

The first patient to receive a modern antidepressant was Paula J. F., a Swiss woman admitted to the Munsterlingen asylum with depression. Her psychiatrist, Roland Kuhn, was a prominant Swiss psychoanalyst of his day, but also had an interest in organic psychiatry, having been one of the pioneers in the use of EEGs. At the time, antihistamines were being

Do Antidepressants Cause Switching?

Topics: Antidepressants

The latest foray into the controversial issue of antidepressant-induced switching appeared in the February issue of The American Journal of Psychiatry (2006;163:232-239). The last time TCPR took up this topic (June 2005), we reviewed a meta-analysis of antidepressant use in bipolar disorder. That paper concluded that SSRIs cause the same rate of mani

Antidepressants: Does Mechanism Matter?

Topics: Antidepressants

While it’s certainly interesting to theorize about neurotransmitters and antidepressants, the recent STAR*D findings bring up a difficult topic: Does mechanism matter? Recall that the main findings of the second step of STAR*D were that when patients were switched from Celexa to any of three antidepressants (ADs) with different mechanisms of action