Dopamine Carlat Reports | Carlat Publishing

Clinical Update

Nuplazid: Novel Mechanism, Modest Benefits

From The Carlat Psychiatry Report, Psychopharmacology Algorithms

Psychosis can be a paralyzing dilemma for patients with Parkinson’s disease (PD). Most antipsychotics worsen the motor symptoms of PD, while the dopaminergic drugs that treat PD can worsen the psychosis. Psychosis afflicts up to 60% of patients with PD, and it is the leading cause of nursing home placement in these patients (Hacksell U et al, Neuroche

Research Update

Antipsychotics Fall Short in Delirium

From The Carlat Psychiatry Report, Psychopharmacology Algorithms

Review: Oh ES et al, Ann Intern Med 2019;171(7):474–484; Nikooie R et al, Ann Intern Med 2019;171(7):485–495 Study type: Systematic reviews of randomized controlled trials and prospective studies Delirium is common and costly. With an incidence rate approaching 50% in hospitalized older adults, the condition poses a burden that is anticipated

Expert Q&A

Inflammatory Biomarkers in Depression

From The Carlat Psychiatry Report, Inflammation and Depression

TCPR: What is inflammation? Dr. Miller: Inflammation is the body’s natural response to infection or wounding. It’s important for survival, but if it goes on too long it damages the body in various ways. It contributes to heart disease, cancer, metabolic disorders, and neurodegenerative disorders. Ultimately, it can change set points in the brain th

Highlights

Highlights From This Issue

From The Carlat Psychiatry Report, Inflammation and Depression

Inflammation contributes to treatment resistance in depression and can be measured with a blood test, C-reactive protein (CRP). An elevated CRP predicts a favorable response to certain antidepressants, as well as specific lifestyle interventions. Nuedexta’s expanded use in dementia is based on questionable efficacy, but it is safer than many