Genetic Testing in Depression

Topics: GeneSight | Genetic Testing | Genetics and Psychiatry | Pharmacogenomics | Randomized controlled trial | Research | Research Update

REVIEW OF: Perlis RH et al, Depress Anxiety 2020;37(9):834–841 STUDY TYPE: Randomized controlled trial By tailoring medications to a patient’s genetic profile, pharmacogenomics promises less medication trial and error, fewer side effects, and better overall outcomes. But does knowing a patient’s pharmacogenetic profile really improve treatme

Genetic Testing: What You Need to Know in 2021

Topics: Autism Spectrum Disorder | CYP2C19 | CYP2D6 | GeneSight | Genetic Testing | Genetics and Psychiatry | Laboratory Testing in Psychiatry | Learning & Developmental Disabilities | Pharmacogenomics | Treatment-Resistant Depression | Whole Genome Sequencing

TCPR: Is there a role for genetic testing in clinical practice? Dr. Nurnberger: I think the evidence is growing that there’s a place for this in clinical practice. The meta-analyses of pharmacogenetic tests are actually looking pretty favorable recently, at least for some genes, particularly CYP2D6 and 2C19 (Bousman CA et al, Pharmacogenomics 2019;20

Pharmacogenetic Testing: An Update

Topics: Diagnostic Testing | Free Articles | Genetics and Psychiatry | Laboratory Testing in Psychiatry | Practice Tools and Tips

Given how many essentially equivalent medications we have to choose from, how great would it be to have a test that tells us which drug to prescribe for which patient? Everybody wants personalized medicine, and in some other specialties, such as oncology, this is becoming a standard part of treatment. In this article, we’ll review some of the basics o

Understanding Pharmacogenetics Research

Topics: Diagnostic Testing | Genetics and Psychiatry | Laboratory Testing in Psychiatry | Practice Tools and Tips

TCPR: Dr. Uher, you have been a co-investigator on the major studies of pharmacogenetics in psychiatry. It’s a complicated field, and I thought you could explain how the research is actually done. Dr. Uher: The basic goal of this kind of research is to try to find an association between a genetic variant and the clinical response to a particular m

Live Chat: What should you know about psychiatric genetic testing?

Topics: Genetics and Psychiatry

Background: Recently, The Boston Globe ran an article that picked up on The Carlat Psychiatry Report's recent coverage of the GeneSight test. It's a promising technology, but the marketing has leap-frogged ahead of the science.  Web Chat Panel: Daniel Carlat, MD, Founder and Editor-in-Chief of The Carlat Psychiatr

Transcribed Web Chat: What should you know about psychiatric genetic testing?

Topics: Genetics and Psychiatry

Using Psychiatric Biomarkers in your Practice

Topics: Addiction | Diagnostic Testing | Genetics and Psychiatry | Laboratory Testing in Psychiatry | Practice Tools and Tips

Treatment of the psychiatric patient is as much an art as it is a science. Diagnosing and deciding on treatments in psychiatry is based on a series of human interactions. We observe and we listen to patients, we ask questions, we consider their responses, and we synthesize all this information in order to render a judgment. Such judgments are subjective

The GeneSight Genetic Test: A Review of the Evidence

Topics: Diagnostic Testing | Genetics and Psychiatry | Pharmaceutical Industry | Practice Tools and Tips

Assurex Health recently sent me an email inviting me to dine at Legal Seafood to learn about “Clinical Applications of Psychiatric Pharmacogenetics.” I didn’t go, but increasingly I am hearing from colleagues about their experiences at these dinner programs: “What do you think about this GeneSight test? The data looked pretty impressive at this

How to Evaluate the Methodology of Biomarker Studies

Topics: Addiction | Genetics and Psychiatry | Laboratory Testing in Psychiatry | Practice Tools and Tips

Pharmacogenetic Testing in Clinical Psychiatry

Topics: Genetics and Psychiatry

“Personalized medicine” is a buzzword in healthcare and stems from the idea that treatments can be designed specifically for a patient, based on his or her own biological characteristics. In psychiatry, personalization is largely based on “pharmacogenetics,” the selection of medications based on genetic factors associated with drug response a

The Uses of Pharmacogenetic Testing

Topics: Genetics and Psychiatry

Psychological Evaluation of Patients Prior to Bariatric Surgery

Topics: Genetics and Psychiatry | Psychotherapy

The Growing Epidemic of Pediatric Obesity

Topics: Genetics and Psychiatry | Psychotherapy

We are all increasingly asked to identify, assess, and treat overweight and obese children and adolescents. What’s behind what many see as a growing epidemic of childhood obesity in the US? And what are the most effective pscyhosocial interventions for these children? Research has shown that multiple factors play a role in a child or adolescent

You are What is Eating You—The Genetics, Environment, and Behavior of Obesity

Topics: Genetics and Psychiatry | Psychotherapy

It is a sobering fact that more than a third of America’s adults are obese, along with nearly 18% of US children. Weight gain is more complex than a simple mathematical equation (Caloric Intake > Caloric Expenditure = Weight Gain). A constellation of genetics, environment, and behavior contribute to obesity. In this article, we’ll expl

Children of Young Moms or Old Dads Most Likely to Develop Psychiatric Disorders

Topics: Genetics and Psychiatry | News of Note

Is Pharmacogenetic Testing Used—and Useful—in Clinical Practice?

Topics: Genetics and Psychiatry | Research Updates

Subject: GENETICS Short Description: Is Pharmacogenetic Testing Used—and Useful—in Clinical Practice? Background: For years, we have read articles about the promise of pharmacogenetic testing to help us choose and monitor medication treatment. But relatively few psychiatrists actually use the cytochrome P450 (CYP450) genotyping tests that

Genes Plus Environment in Psychiatry: View Positive Studies Skeptically

Topics: Depressive Disorder | Genetics and Psychiatry

Subject: GENETICS Short Description: Genes Plus Environment in Psychiatry: View Positive Studies Skeptically Background: Common sense dictates that genetic predispositions probably interact with life stressors to influence our mental health. Plenty of research has been published to evaluate whether this is actually true, but findings have bee