Weight gain Carlat Reports | Carlat Publishing

Clinical Update

Medication Management of Antipsychotic-Induced Weight Gain in Children and Teens

From The Carlat Child Psychiatry Report, Eating Disorders in Children and Adolescents

Of approximately one million US children and adolescents, roughly 1% are prescribed second-generation antipsychotics (SGAs). These medications routinely breach the FDA’s level of concern of >7% body weight gain. The worst offenders are olanzapine, quetiapine, and risperidone; lurasidone and ziprasidone are of less concern (Maayan L and Correll CU,

Research Update

Topiramate Improves Weight in Schizophrenia in South Asians

From The Carlat Psychiatry Report, Psychotic Depression

Topics: Metabolic syndrome | Schizophrenia | Special populations | Topiramate | Weight gain

REVIEW OF: Chandradasa M et al, Asian J Psychiatr 2022;68:102963 STUDY TYPE: Randomized placebo-controlled trial People with schizophrenia have higher rates of cardiometabolic mortality. There is meta-analytic evidence that adjunctive topiramate reduces weight and improves psychiatric symptoms in schizophrenia. However, there are few studies of th

Clinical Update

Tricyclic Antidepressants: When and How to Use Them

From The Carlat Psychiatry Report, Race and Mental Health

Topics: Antidepressants | Dosing | Side Effects | Treatment-Resistant Depression | Weight gain

Tricyclics have been used in psychiatry since the 1950s, when imipramine was introduced as the first mass-marketed antidepressant. Fluoxetine and the other SSRIs largely supplanted the tricyclics in the 1990s, but these medications still have their uses. There are two kinds of tricyclics: Tertiary amines—the “originals” Secondary amines—t

Clinical Update

Battle of the Bulge: Obesity and Antipsychotic-Induced Weight Gain

From The Carlat Hospital Psychiatry Report, Metabolic Side Effects

Topics: | | | | | | | | | | | | | | | | | | | | Aripiprazole Benzphetamine Bupropion Diabetes Diethylpropion Exercise Insulin resistance Liraglutide Metabolic syndrome Metformin Naltrexone olanzapine Phendimetrazine Phentermine Samidorphan Semaglutide Side Effects Topiramate Waist circumference Weight gain Ziprasidone

Many psychiatric medications cause weight gain, including mood stabilizers, antidepressants, and especially antipsychotics. Most weight gain secondary to antipsychotic use occurs in the first 6 months of therapy, so it’s important to monitor weight closely and intervene early in a patient’s treatment. We counsel patients at every visit about healthy

Expert Q&A

Weight Gain and Metabolic Side Effects

From The Carlat Hospital Psychiatry Report, Metabolic Side Effects

CHPR: Dr. Marder, can you please tell us about your work? Dr. Marder: Sure. My work has focused on pharmacologic and nonpharmacologic approaches to improving the outcomes of serious mental illnesses, particularly schizophrenia. I’m very interested in ways to combine psychosocial interventions with pharmacological approaches and to reduce adverse side

Research Update

New Combination Treatment Mitigates Antipsychotic-Induced Weight Gain

From The Carlat Hospital Psychiatry Report, Metabolic Side Effects

Review of: Correll CU et al, Am J Psychiatry 2020;177(12):1168–1178 To date, we have had no FDA-approved medications to mitigate antipsychotic-associated weight gain (AIWG). This will soon change, thanks to recent research showing that samidorphan, an opioid receptor antagonist, appears to significantly lessen weight gain associated with the use

Research Update

Weight Gain From Aripiprazole Same as Risperidone

From The Carlat Child Psychiatry Report, Autism in Children and Adolescents

Review of: Schoemakers RJ et al, J Child Adolesc Psychopharm 2019;29(3):192–196 Many providers prefer aripiprazole over risperidone for young patients due to observed lower incidence of weight gain. This is supported in studies with follow-up of less than 3 months. However, does aripiprazole fare better with long-term use? Researchers reviewed r

In Brief

Lybalvi: The Diet Olanzapine

From The Carlat Psychiatry Report, Schizophrenia

Lybalvi is a new combo pill that aims to overcome the dreaded metabolic effects of olanzapine by pairing it with the opioid antagonist samidorphan. Patients still gain weight on Lybalvi, though not as much as they do on olanzapine. In the three controlled trials that compared the two drugs, the weight gain on Lybalvi was 5 lb less at six months, 3 lb le

Brief Clinical Update

Metformin ER Recalled Due to Cancer Risk

From The Carlat Psychiatry Report, Practical Psychotherapy

Topics: Antipsychotics | Generics | Metformin | Weight gain | Weight Loss Medications

Metformin is often prescribed to our patients to prevent weight gain on antipsychotics, but recently the FDA discovered that large batches of various metformin ER formulations may be contaminated with a carcinogen. Voluntary recalls of metformin ER began in May 2020 and have continued to the present. The result is drug shortages, fear, and an unanswered