Apparent effectiveness of antidepressants is inflated by publication bias
The Carlat Psychiatry Report, Volume 6, Number 4, April 2008
https://www.thecarlatreport.com/newsletter-issue/tcprv6n4/
Issue Links: Learning Objectives | Editorial Information
Topics: Antidepressants
Mark Willenbring, MD
A former FDA reviewer and his colleagues obtained all FDA data on studies of 12 antidepressants approved between 1987 and 2004. They then scoured the journals to figure which of these studies had been published. They found that of the 74 FDA-registered trials of antidepressants, 23 (31%) had never been published.
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Mark Willenbring, MD
Director, Division of Treatment and Recovery National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Dr. Willenbring discloses that he has no relationships with commercial entities related to the content of this educational activity. Dr. Willenbring discloses that topiramate is not approved for the treatment of alcohol dependence. Please refer to product labeling for approved uses.