Excessive salivation is a common and troubling adverse effect of clozapine therapy, occurring in about 30% of patients. Recently, Israeli researchers evaluated another potential treatment, metoclopramide (Reglan), which is a drug for nausea and other gastrointestinal problems. Since metoclopramide commonly causes dry mouth, the authors of this paper reasoned that it might work for clozapine-induced hypersalivation.

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