Antidepressants and Suicidal Ideation in Young People: A Practical Approach

Topics: Antidepressants | Child Psychiatry | Depressive Disorder

Many of you will remember that in October of 2004, the FDA announced to drug companies that they should add black-box warnings about the risk of suicidal behavior in children and adolescents started on antidepressants. This was based on an analysis of placebo-controlled, randomized trials (a total of 24 trials involving over 4,400 patients) showing that

Antidepressant Use in Children and Teenagers

Topics: Antidepressants | Child Psychiatry | Depressive Disorder | Free Articles | Practice Tools and Tips | Psychopharmacology Tips

Rexulti for Schizophrenia and MDD: Is It Abilify, Round 2?

Topics: Antidepressants | Depressive Disorder | News of Note

Trauma Systems Therapy

Topics: Antidepressants | Anxiety Disorder | Child Psychiatry | Practice Tools and Tips | Psychopharmacology Tips | Psychotherapy | PTSD

Debate Rages On Over ‘Black Box’ Warning on Antidepressants

Topics: Antidepressants | News of Note | Risk Management

Physicians May Overprescribe Antidepressants Based on Brief Depression Questionnaires

Topics: Antidepressants | Research Updates

Does Dose Matter When it Comes to Antidepressants and Self-Harm?

Topics: Antidepressants | Child Psychiatry | Depressive Disorder

New Study Supports Cardiac Safety of SSRIs in Pregnancy

Topics: Antidepressants | Research Updates | Women's Issues in Psychiatry

Move Over Ketamine? New Fast-Acting Antidepressant Shows Promise

Topics: Antidepressants | News of Note

Dealing With Side Effects of SSRIs

Topics: Antidepressants | Antipsychotics | Child Psychiatry | Psychopharmacology Tips

Selective serotonin reuptake inhibitors (SSRIs) are widely used as the first-line treatment for depression and anxiety in children and adolescents, but they are associated with significant adverse effects (AEs). Studies have shown that up to 50% of kids experience side effects from SSRIs, depending on the sample size and the type of study. The most c

Metabolic and Extrapyramidal Effects of Antipsychotics

Topics: Antidepressants | Antipsychotics | Child Psychiatry | Psychopharmacology Tips

Table 1: Risks of Side Effects of Antipsychotics in Children and Adolescents Click here to open pdf

Non-Physical Adverse Effects of ADs May Be Underreported

Topics: Antidepressants | Research Updates

Does Brintellix Bring Anything New?

Topics: Antidepressants | Depressive Disorder

After a dry spell of new antidepressants—the last one to be approved was levomilnacipran (Fetzima), the active enantiomer of milnacipran (Savella) in July 2013—the FDA approved vortioxetine (Brintellix) in September. Vortioxetine is another serotonergic antidepressant. How exactly does it work, and what are its advantages over existing drugs? Vor

Do NSAIDs Keep Antidepressants From Working?

Topics: Antidepressants

Anti-Inflammatory Drug an Antidepressant?

Topics: Antidepressants | Research Updates

Subject: Depression Short Description: Anti-Inflammatory Drug an Antidepressant? Background: It seems that not a week goes by without another research paper drawing attention to the interface between immunology and psychiatry, or about biomarkers to predict response to psychotropic medications. A recent report from researchers at Emory Univer

Is It Possible that Antidepressants Really Don’t Work?

Topics: Antidepressants

A heated debate over how well psychiatric medications actually work has led some authorities in our field to suggest that psychiatry is currently experiencing a “crisis of confidence” (Nierenberg AA et al, J Clin Psychiatry 2011;72(1):27–33). This debate has even begun to spill over into the mainstream media. Most recently, a 60 Minutes exposé su

Future Developments in Antidepressant Therapy

Topics: Antidepressants

In 2011 in the pages of TCPR, we asked, “What’s new in antidepressant treatment?” The answer was “not much” (TCPR, April 2011). In 2012, unfortunately, the answer isn’t very different. Given the high cost ($1.8 billion) and long time (almost nine years, on average) to bring a new antidepressant to market, drug companies are putting fewer

Can a Blood Test Diagnose Depression?

Topics: Antidepressants

Subject: Depression Short Description: Can a Blood Test Diagnose Depression? Background: Psychiatrists have long wondered whether someday we might have an objective way to diagnose depression, in much the same way an internist orders a blood test or X-ray. A recent article suggests that just such a test might be on the horizon. Is it the real

FDA Publishes Article Critical of Vilazodone Data

Topics: Antidepressants | Research Updates

Subject: ANTIDEPRESSANTS Short Description: FDA Publishes Article Critical of Vilazodone Data Background: It has been over a year now since the approval of vilazodone (Viibryd). As you may recall from our review of the drug in TCPR April 2011, vilazodone is an SSRI with partial agonism at the 5HT1A receptor. This “dual mechanism” of act

Psychotherapy for Pediatric PTSD

Topics: Antidepressants | Anxiety Disorder | Free Articles | Psychotherapy | PTSD

Karina’s foster mom brought her to my office last year for irritability and “mood swings.” A soft-spoken fourteen year old, Karina (and her nine year old brother) had been with the family for three months, and her foster family reported that “little things” set her off into explosive anger. Sometimes she seemed tense or didn’t want to go out