Clozapine for Conduct Disorder in Schizophrenia

Topics: Clozapine | Conduct Disorder | Schizophrenia | Violence

REVIEW OF: Krakowski M et al, Am J Psychiatry 2021;178(3):266–274 STUDY TYPE: Randomized controlled trial We often struggle to find effective interventions for aggressive behavior in patients with schizophrenia. For patients with a history of conduct disorder, the task is even more challenging. Patients with schizophrenia will often have shown s

Sublingual Atropine Drops and Clozapine-Induced Drooling

Topics: Atropine | Clozapine | Drooling | hypersalivation | Side Effects

REVIEW OF: Mubaslat O and Lambert T, Psychopharmacology (Berl) 2020;237(10):2905–2915 STUDY TYPE: Randomized placebo-controlled trial Excessive salivation or drooling is one of the more troublesome side effects of clozapine, occurring in up to 80% of patients. It is embarrassing for patients and is a factor in drug discontinuation. Aspiration pn

Weight Gain and Metabolic Side Effects

Topics: Aripiprazole | Clozapine | Diabetes | Exercise | Insulin resistance | Liraglutide | Metabolic syndrome | Metformin | olanzapine | Quetiapine | Risperidione | Samidorphan | Side Effects | Topiramate | Waist circumference | Weight gain | Ziprasidone

CHPR: Dr. Marder, can you please tell us about your work? Dr. Marder: Sure. My work has focused on pharmacologic and nonpharmacologic approaches to improving the outcomes of serious mental illnesses, particularly schizophrenia. I’m very interested in ways to combine psychosocial interventions with pharmacological approaches and to reduce adverse side

A Potentially Lethal Side Effect You Probably Never Heard Of

Topics: Clozapine | FDA Warnings | Free Articles | Management | Psychosis | Schizophrenia

In January 2020, the FDA issued a strong warning about constipation on clozapine. With a fatality rate of 1 in 1000, this is not just a nuisance side effect, and it can happen with other antipsychotics and psychotropics as well. This type of constipation is caused by slowing of the gut, or gastric hypomotility, and it requires a unique approach. Fiber s

Raising the Bar in Schizophrenia Treatment

Topics: Clozapine | Negative Symptoms | Psychosis | Schizophrenia | Second Generation Antipsychotics (SGAs)

TCPR: Antipsychotics are the standard of care in schizophrenia, but what can we do beyond that? Dr. Miller: Several things come to mind. Therapeutic alliance, addressing the full symptom picture, and greater use of clozapine in treatment-resistant cases. TCPR: Let’s start with therapeutic alliance. Dr. Miller: Nonadherence with medications is the

The Schizophrenia-OCD Overlap

Topics: Antipsychotics | Aripiprazole | Clozapine | Comorbidity | Diagnosis | Lamictal | Lamotrigine | Obsessive Compulsive Disorder | OCD | olanzapine | Pharmacology Tips | polypharmacy | Quetiapine | Risperidone | Schizoaffective disorder | Schizophrenia

TCPR: What is schizo-obsessive disorder?Dr. Poyurovsky: Schizo-obsessive disorder (schizo-OCD) is not a DSM diagnosis. The term is used to refer to patients with schizophrenic disorders that have comorbid features of OCD. We see these obsessive-compulsive symptoms in schizophrenia more often than would be expected by chance. About one in four patients h

How to Choose an Antipsychotic in Schizophrenia

Topics: Antipsychotics | Aripiprazole | Cariprazine | Clozapine | Negative Symptoms | olanzapine | Psychopharmacology | Psychopharmacology Tips | Psychosis | Risperidone | Schizophrenia

It’s been over a decade since the CATIE trial changed the way we look at antipsychotic drugs. Since then, the number of second-generation antipsychotics has about doubled, and the number of clinical trials has risen even more. Antipsychotics are not all the same, though, and when it comes to schizophrenia, a few stand out in ways that can help you fin