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Clinical Update

Battle of the Bulge: Obesity and Antipsychotic-Induced Weight Gain

From The Carlat Hospital Psychiatry Report, Metabolic Side Effects

Topics: | | | | | | | | | | | | | | | | | | | | Aripiprazole Benzphetamine Bupropion Diabetes Diethylpropion Exercise Insulin resistance Liraglutide Metabolic syndrome Metformin Naltrexone olanzapine Phendimetrazine Phentermine Samidorphan Semaglutide Side Effects Topiramate Waist circumference Weight gain Ziprasidone

Many psychiatric medications cause weight gain, including mood stabilizers, antidepressants, and especially antipsychotics. Most weight gain secondary to antipsychotic use occurs in the first 6 months of therapy, so it’s important to monitor weight closely and intervene early in a patient’s treatment. We counsel patients at every visit about healthy

Expert Q&A

Weight Gain and Metabolic Side Effects

From The Carlat Hospital Psychiatry Report, Metabolic Side Effects

CHPR: Dr. Marder, can you please tell us about your work? Dr. Marder: Sure. My work has focused on pharmacologic and nonpharmacologic approaches to improving the outcomes of serious mental illnesses, particularly schizophrenia. I’m very interested in ways to combine psychosocial interventions with pharmacological approaches and to reduce adverse side

Expert Q&A

Probiotics in Psychiatry

From The Carlat Psychiatry Report, Mind-Gut Connection

TCPR: What is the gut microbiome? Dr. Dinan: It is the collection of microorganisms within the intestine. It functions like a separate organ and is about the same weight as an adult brain. Mainly it’s made up of bacteria, which is where our research has focused, but there are viruses and fungi in there as well. The traditional view was that these org

Expert Q&A

Side Effects of Psychotherapy

From The Carlat Psychiatry Report, Practical Psychotherapy

TCPR: What are side effects to psychotherapy?Dr. Linden: Side effects are adverse reactions to a therapy that is correctly applied. TCPR: Why do you say “correctly” applied?Dr. Linden: When I talk about side effects, I’m not talking about boundary violations or mistakes by the therapist. I’m talking about unwanted events that are caused by the

Expert Q&A

Brief Therapy During the Medication Visit

From The Carlat Psychiatry Report, Practical Psychotherapy

TCPR: How does a brief therapy session differ from the 50-minute hour?Dr. Sudak: What’s different is the scope of what you can tackle in those 25–30 minutes. There’s a greater need to organize the session and make decisions about what you can take on. For example, trauma is a subject that you’d probably defer to a longer session. TCPR: How do y

Expert Q&A

Inflammatory Biomarkers in Depression

From The Carlat Psychiatry Report, Inflammation and Depression

TCPR: What is inflammation? Dr. Miller: Inflammation is the body’s natural response to infection or wounding. It’s important for survival, but if it goes on too long it damages the body in various ways. It contributes to heart disease, cancer, metabolic disorders, and neurodegenerative disorders. Ultimately, it can change set points in the brain th

Highlights

Highlights From This Issue

From The Carlat Psychiatry Report, Inflammation and Depression

Inflammation contributes to treatment resistance in depression and can be measured with a blood test, C-reactive protein (CRP). An elevated CRP predicts a favorable response to certain antidepressants, as well as specific lifestyle interventions. Nuedexta’s expanded use in dementia is based on questionable efficacy, but it is safer than many